GNRH ANTAGONIST PROTOCOL VERSUS GNRH AGONIST LONG PROTOCOL: A RETROSPECTIVE COHORT STUDY ON CLINICAL OUTCOMES AND MATERNAL-NEONATAL SAFETY

GnRH Antagonist Protocol Versus GnRH Agonist Long Protocol: A Retrospective Cohort Study on Clinical Outcomes and Maternal-Neonatal Safety

ObjectiveTo evaluate the clinical outcomes and maternal-neonatal safety of gonadotropin releasing hormone antagonist (GnRH-ant) and gonadotropin releasing hormone agonist (GnRH-a) protocols.MethodsA total of 2505 women undergoing their first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were retrospectively analyzed.Patients

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Differential enrichment of H3K9me3 at annotated satellite DNA repeats in human cell lines and during fetal development in mouse

Abstract Background Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows differences associated with various processes such as development and malignant transformation.However, the dynamics of H3K9me3 at distal satellite DNA repeats has not been

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EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics

Abstract DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour typing with unprecedented precision, has quickly become a new standard of care.Whereas genome-wide diagnostic methylation profiling is mostly performed on microarrays, an increasing number of institutions addition

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